ALVOPREL (irbesartan) belongs to a group of medicines known as angiotensin II receptor antagonists.

Angiotensin II is a substance produced in the body which binds to receptors in blood vessels causing them to tighten. This results in an increase in blood pressure. ALVOPREL prevents the binding of angiotensin II to these receptors, causing the blood vessels to relax and the blood pressure to lower. This medicine stows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

ALVOPREL is used in adult patients:

• To treat high blood pressure (essential hypertension)
• To protect the kidney in patients with high blood pressure, type 2 diabetes and laboratory evidence of impaired kidney function

It is proven in clinical studies that irbesartan either as monotherapy or in combination with other antihypertensive agents can achieve significant reductions in both systolic and diastolic blood pressures compared with alternative treatment options. Irbesartan also has a renoprotective effect independent of its blood pressure-lowering in patients with type 2 diabetes and nephropathy. Furthermore, irbesartan has an excellent safety and tolerability profile and is proven to be a cost-effective treatment in terms of economic analyses.

Please refer to the full prescribing information for more details.